Process Research & Development and Analytical Laboratories
Where process development and understanding happen simultaneously.
Small molecule API and KSM development where process understanding and optimization happen concurrently, not sequentially. Advanced manufacturing technologies deliver route scouting through cGMP-ready packages.
Concurrent Development
Process safety, analytical characterization, and chemistry optimization run in parallel.
Process safety, analytical characterization, and chemistry optimization run in parallel.
Batch & Continuous Flow
Industrial-scale flow reactors and batch platforms determine optimal synthesis architecture for your molecule.
Industrial-scale flow reactors and batch platforms determine optimal synthesis architecture for your molecule.
Real-Time Analytics
ReactIR, ReactRaman, inline NMR, and mass spec provide live process monitoring during active synthesis.
ReactIR, ReactRaman, inline NMR, and mass spec provide live process monitoring during active synthesis.
QbD-Aligned Packages
CMC data packages designed for regulatory submission and commercial lifecycle management.
CMC data packages designed for regulatory submission and commercial lifecycle management.
At Phlow, manufacturability is designed—not discovered at scale.
Phlow’s Richmond laboratories are where API programs take shape. The fundamental design principle: process safety, analytical development, and chemistry optimization run concurrently, ensuring that hazard profile, impurity landscape, and process parameters are fully characterized before any program advances to cGMP manufacturing.
Laboratory Infrastructure
5000
5,000 sq. ft. dedicated lab space
5,000 sq. ft. dedicated lab space
4+8
walk-in + bench fume hoods
walk-in + bench fume hoods
100%
100% QbD-aligned development
100% QbD-aligned development
Flow Synthesis Platforms
Phlow’s labs integrate batch and continuous flow development platforms to determine the optimal synthesis architecture for each molecule—batch, flow, or hybrid—with a direct line of sight to commercial execution.
Corning Advanced-Flow Reactor
Industrial-scale continuous synthesis. Handles corrosive and exothermic chemistries at commercially relevant throughputs.
Industrial-scale continuous synthesis. Handles corrosive and exothermic chemistries at commercially relevant throughputs.
Phoenix Flow Reactor
Purpose-built for hazardous chemistries including azidations, diazotizations, and nitrations.
Purpose-built for hazardous chemistries including azidations, diazotizations, and nitrations.
H-Cube Systems
Continuous-flow hydrogenation under elevated pressure and temperature, without bulk hydrogen storage.
Continuous-flow hydrogenation under elevated pressure and temperature, without bulk hydrogen storage.
EasyMax 402 (400 mL)
Automated batch platform for parallel process optimization, calorimetry, and development prior to flow or scale translation.
Automated batch platform for parallel process optimization, calorimetry, and development prior to flow or scale translation.
Real-Time Process Analytics
ReactIR — Inline Infrared Spectroscopy
Tracks reaction progress, intermediate formation, and endpoint—in real time, without manual sampling.
Tracks reaction progress, intermediate formation, and endpoint—in real time, without manual sampling.
ReactRaman — In-Situ Raman Spectroscopy
Complementary process characterization and solid-form monitoring in crystallization steps.
Complementary process characterization and solid-form monitoring in crystallization steps.
80 MHz NMR with Flow Cell
Structural confirmation during active continuous synthesis runs.
Structural confirmation during active continuous synthesis runs.
Mass Spectrometry
Structural confirmation and impurity identification throughout development.
Structural confirmation and impurity identification throughout development.
Process Safety Built Into Development
Process safety investigations and calorimetric measurements are conducted alongside chemistry development, ensuring thermal risk, reaction energetics, and scale feasibility are understood before cGMP manufacturing begins.
Hazard profiling is not an afterthought—it’s integrated into every stage of process development, providing your program with a complete safety and scalability assessment from day one.
Chemical Development Scope
Phlow’s process chemistry team executes across the full range of transformations required for complex small molecule APIs, including the hazardous and technically demanding reactions that define differentiated programs.
Catalysis & Coupling
- Organometallics
- Metal-Mediated Couplings
- Heterogeneous/Homogeneous Catalysis
- Non-Precious Metal Catalysis
- Hydrogenation
- Biocatalysis
Hazardous & Controlled Chemistry
- Azidation
- Nitrations
- Nitrosamines
- Pyrophoric Reagents
- High-Pressure Chemistry
- Methylating Agents
- Cyanation
- Controlled Substance
Functional Transformations
- Chiral Synthesis
- Alkylations
- Acylations
- Nucleophilic Aromatic Substitution
- Electrochemistry
- Photochemistry
- Low Temp/High-Temp
Isolation, Purification & Analytical
- Continuous Crystallization
- Chromatography
- Solid State Chemistry
- Residual Solvent and Water Content
Led by Experienced Process Chemists and Analytical Scientists.
Rustam Garrey, PhD
Vice President of Process Chemistry — Manufacturing, Science & Technology
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