Strategic Active Pharmaceutical Ingredient Reserve (SAPIR®)

A strategic inventory of critical and essential ingredients that can be converted rapidly to finished drug products in case of emergency.

Caretaker of America's Medicine Source.

The Strategic Active Pharmaceutical Ingredient Reserve (SAPIR®), powered by Phlow, is a forward-leaning, intelligent system that identifies supply chain risks in real time, maintains a reserve of long shelf-life precursor chemicals and APIs, and enables rapid formulation and fill-finish when a public health emergency occurs, held on U.S. soil so the country is never again dependent on foreign supply in a crisis.

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Powered by Phlow, SAPIR is a living program that incorporates infrastructure, technology, policy, and public-private partnerships to ensure immediate readiness. Its core components include:

Domestic Manufacturing Capacity

Purpose-built U.S. facilities and contract relationships for the domestic production of critical Active Pharmaceutical Ingredients (APIs) and Key Starting Materials (KSMs).

Distributed Ingredient Storage Network

A geographically diverse network of secure, cyber- and physically protected storage facilities located across the United States to ensure resilience and regional response capability.

Analytical Testing Infrastructure

Facilities and protocols to verify quality, purity, and regulatory compliance of all stored and incoming critical ingredients.

Conversion Capabilities

A national network of ready-to-activate partners, including 503B compounding pharmacies and commercial manufacturing firms, equipped to rapidly convert APIs into finished drug products.

Digital Operations Hub

A centralized digital command center managing real-time inventory tracking, demand forecasting, procurement, and rapid deployment logistics through end-to-end supply chain visibility and AI-enabled readiness analytics.

Fully prepared for disruption to mitigate drug shortages.

In the event of declared public health emergencies, war or trade-related disruptions, weather-related events, or other events that can lead to essential medicine supply chain disruptions or shortages, the critical ingredients in the SAPIR can be rapidly converted to finished essential medicine and medical countermeasure products. This enables swift distribution of essential medications during emergencies.

Graphic showing SAPIR conversion strategy

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