A strategic inventory of critical and essential ingredients that can be converted rapidly to finished drug products in case of emergency.
Providing U.S. Pharmaceutical Security.
The Strategic Active Pharmaceutical Ingredient Reserve (SAPIR) is not simply a storage warehouse, it is an active, integrated, and mission-critical operational system designed to safeguard the nation’s access to essential medicines and pharmaceutical ingredients in times of disruption or emergency.
SAPIR is a living program that incorporates infrastructure, technology, policy, and public-private partnerships to ensure immediate readiness. Its core components include:
Domestic
Manufacturing Capacity
Purpose-built U.S. facilities and contract relationships for the domestic production of critical APIs and KSMs.
Distributed Ingredient
Storage Network
A geographically diverse network of secure, cyber- and physically protected storage facilities located across the United States to ensure resilience and regional response capability.
Analytical Testing
Infrastructure
Facilities and protocols to verify quality, purity, and regulatory compliance of all stored and incoming critical ingredients.
Conversion
Capabilities
A national network of ready-to-activate partners, including 503B compounding pharmacies and commercial manufacturing firms, equipped to rapidly convert APIs into finished drug products.
Digital
Operations Hub
A centralized digital command center managing real-time inventory tracking, demand forecasting, procurement, and rapid deployment logistics through end-to-end supply chain visibility and AI-enabled readiness analytics.
Fully prepared for disruption to mitigate drug shortages.
In the event of declared public health emergencies, war or trade-related disruptions, weather-related events, or other events that can lead to essential medicine supply chain disruptions or shortages, the critical ingredients in the SAPIR can be rapidly converted to finished essential medicine and medical countermeasure products. This enables swift distribution of essential medications nationwide during emergencies.
