Modernize your small molecule API development & manufacturing.
WITH CDMOX BY PHLOW
- Utilize 12 principles of green chemistry
- Manufacture 100% within the United States
- Create manufacturing redundancy in the U.S.
- Ensure the highest quality and reliability
- Reduce environmental impact
- Bespoke support by Phlow experts
WITH CDMOX BY PHLOW
- Utilize 12 principles of green chemistry
- Manufacture 100% within the United States
- Create manufacturing redundancy in the U.S.
- Ensure the highest quality and reliability
- Reduce environmental impact
- Bespoke support by Phlow experts
Our Technologies.
Phlow provides a wide range of best-in-class technologies to modernize, support, and accelerate the production of your small molecule API.
Phlow provides a wide range of best-in-class technologies to modernize, support, and accelerate the production of your small molecule API.
- Flow Chemistry
- Chiral Synthesis
- Hazardous Reactions
- Low Temp/High-Temp
- Non-Precious Metal Catalysis
- High-Pressure Chemistry
- Electrochemistry
- Photochemistry
- Controlled Substance
- Biocatalyis
Phlow Corporate Headquarters
Petersburg Campus
Kilo-Scale cGMP Facility
Phlow’s Advanced Manufacturing Facilities.
Phlow’s Research & Development Laboratory
Kilo-Scale cGMP Facility
Metric Ton-Scale cGMP Facility
Phlow’s Research & Development Laboratory
Richmond, VA
Phlow’s state-of-the-art R&D lab is at the Advanced Pharmaceutical Development Center (APDC) at Virginia Biotechnology Research Park in Richmond, VA. At the APDC, Phlow leverages advanced manufacturing technologies using the latest process and analytical equipment.
CHEMICAL DEVELOPMENT
PROCESS SAFETY STUDIES
PROCESS AND ANALYTICAL EQUIPMENT
CHEMICAL DEVELOPMENT
- Fluorination
- Hydrogenation
- Cyanation
- Azidation
- Cryogenic Chemistry
- Methylating Agents
- Chromatography
- Heterogeneous/Homogeneous Catalysis
- Nitrations
- Metal-Mediated Couplings
- Alkylations
- Acylations
- Nucleophilic Aromatic Substitution Reactions
- Pyrophoric Reagents
- Synthesis of Reference Standard Samples
- Organic Chemical Process Development
- Advanced technology: Biocatalysis
PROCESS SAFETY STUDIES
- Process Safety Investigations
- Calorimetric Measurements
PROCESS AND ANALYTICAL EQUIPMENT
- EasyMax 402
- Jacketed Reactors
- Various Sized CSTRs
- Various Pumps
- Mass Flow Meters
- IR/Raman with Probe
- LCMS – Triple-Quadrupole
- LCMS – QToF
- GC-Mass Spectrometer
- HPLCs/UPLCs
- Benchtop 80MHz NMR w/ Flow Cell
- Phoenix Flow Reactor
- H-Cube Systems
- Corning Advanced-Flow Reactor
- Differential Scanning Calorimeter
- Hydrogenation Equipment
Kilo-Scale cGMP Facility
Petersburg, VA
ANNUAL CAPACITY OF 500 KG
Phlow’s Kilo Facility is a state-of-the-art manufacturing site with the capacity to produce up to 500 kg of API annually using both batch and continuous processes. It features highly automated equipment, 100 L reactors spread across two cGMP suites, and additional non-cGMP and R&D lab space with 12 fume hoods, analytical support, and an automation lab.
EQUIPMENT
- 2 cGMP suites & 1 non-cGMP suite
- 2 in each of 2 cGMP Kilo rooms
- 2 in the Continuous Lab (non-cGMP)
- 6 Support Tanks for each cGMP Hood (24 total)
- Hastelloy and 316 L SS
- 10 gal and 20 gal
- Agitated and Jacketed
CAPABILITIES
Capable of producing quantities of API in the range of up to ~2 kg/day, depending upon the nature and complexity of the API process.
Metric Ton-Scale Facility
Petersburg, VA
ANNUAL CAPACITY 60 MT
Phlow’s Metric Ton-Scale Facility can produce 60 metric tons of API annually, through continuous and batch mode production. This large-scale, advanced manufacturing facility is equipped with multiple production lines and dedicated drying suites.
EQUIPMENT
- Eight reactors in a single reactor suite
- Dryer/centrifuge charge & discharge rooms
- Filter/dryer charge and discharge rooms
- 2 Process Equipment Trains, 4 Reactors per Train
- 1,000 gal reactor, 2,000 gal reactors
- Hastelloy
- Glass-lined Steel
- 2,000 gal Hastelloy Filter Reactor (custom design)
- Transfer Booths
- Liquid booths – Level 1
- Solids booths – Level 2
- Filtration & Drying
- Filter Dryer
- Inverting Basket Centrifuge
- Conical Dryer
Download the Brochure
Discover how Phlow can transform your small molecule API development and manufacturing.